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While short-term usage may just produce small, transient effects in the brain, extended substance use changes the brain in fundamental methods that reinforce continued use, such as the strengthening of memory circuits connected with drug taking. Hints that are social (such as being around substance-using pals), geographical (former favorite bars), and physical (experiencing tension) in nature end up being strongly associated with the drug.Brain changes from persistent drug or alcohol use can persist years after an individual quits. This is why people run the risk of regression even after extended periods of abstaining, and in spite of a regression's possibly destructive impacts. More notably, this is why treatment depends on the kind of drug and the specific characteristics of the client.