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While short-term usage may just produce little, transient effects in the brain, extended substance usage changes the brain in basic manner ins which reinforce continued use, such as the strengthening of memory circuits associated with drug taking. Hints that are social (such as being around substance-using pals), geographic (previous favorite bars), and physical (experiencing stress) in nature end up being highly related to the drug.Brain modifications from persistent drug or alcohol use can persist years after a person quits. This is why individuals run the risk of regression even after long durations of abstinence, and regardless of a relapse's potentially terrible effects. More notably, this is why treatment depends upon the type of drug and the individual characteristics of the client.